Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions

Biomaterials
Junsang DohMatthew F Krummel

Abstract

Cell-cell cooperativity in populations of motile and transiently interacting immune cells has been difficult to assess in the absence of tools to control proximity and communication. Here, we describe the generation of cell-laden microwells that can precisely control contact-mediated interactions and multicellular 'quorum' decisions in lymphocytes. Different types of fate decisions for activating T cells can be shown to variously obey 'binary' or 'density' outcomes, correlated with cell-cell contact, using this new platform.

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Citations

Nov 22, 2013·ACS Applied Materials & Interfaces·Jong-Cheol ChoiJunsang Doh
May 2, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Dooyoung LeeDaniel A Hammer
Jun 10, 2014·Annual Review of Chemical and Biomolecular Engineering·Konstantinos TsiorisJ Christopher Love
Nov 17, 2015·International Journal of Molecular Sciences·Amelia Ahmad Khalili, Mohd Ridzuan Ahmad
Jan 3, 2013·Immunological Reviews·Audrey GérardMatthew F Krummel
Jun 22, 2014·Journal of Autoimmunity·Shimrit Adutler-LieberBenjamin Geiger
Mar 17, 2015·Biomaterials·Kwang Hoon SongJunsang Doh
Mar 22, 2016·Scientific Reports·Kwang Hoon SongJunsang Doh
Sep 26, 2020·Scientific Reports·Lauren RomitaDae Kun Hwang
Oct 7, 2010·Biomacromolecules·Hiroharu Ajiro, Mitsuru Akashi
Dec 28, 2017·Bioconjugate Chemistry·HyoungJun ParkJunsang Doh

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