Cell lineage dependent and independent control of Purkinje cell number in the mammalian CNS: further quantitative studies of lurcher chimeric mice

Developmental Biology
K Herrup, K Sunter

Abstract

Recent quantitative studies of lurcher chimeric mice have shown that the adult population of cerebellar Purkinje cells can properly be described as a small number of developmental clones of cells. The clones are not seen as patches of contiguous neurons; rather, the cells of any one clone distribute throughout the half-cerebellum that contains them, intermingling extensively with the Purkinje cells of other linkages. Lurcher----wild-type chimeras were analyzed using the cell autonomous Purkinje-cell-lethal mutant, lurcher (+/Lc), as a cell marker. Cell counts from these chimeras revealed that the number of surviving Purkinje cells was always an integral multiple of a unit clone size. These numerical quanta are the evidence for the existence of Purkinje cell developmental clones. When two different inbred strains of mouse were compared (C3H/HeJ and C57BL/6), the resulting clonal analysis showed that the unit clone size (i.e., the number of Purkinje cells in one quantum) is an autonomous property of the lineage and hence, presumably, intrinsic to the progenitor cell that founded it. The current study uses the lurcher chimeric mouse system to examine the cell lineage relationships among the Purkinje cells of a third inbred strain ...Continue Reading

References

Oct 11, 1979·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K W Caddy, T J Biscoe
Jun 27, 1975·Brain Research·K W Caddy, T J Biscoe
Jan 1, 1976·Journal of Neuropathology and Experimental Neurology·D B Wilson
Jan 1, 1985·Annual Review of Neuroscience·M Jacobson
Jul 1, 1965·The Journal of Cell Biology·M Atlas, V P Bond
Jul 15, 1981·Developmental Biology·M L Oster-Granite, J Gearhart
Jun 3, 1961·Nature·A K TARKOWSKI
Oct 1, 1961·Experimental Neurology·I L MIALE, R L SIDMAN

❮ Previous
Next ❯

Citations

Jul 1, 1992·Developmental Biology·T S Musci, R J Mullen
Jan 1, 1989·Brain Research. Developmental Brain Research·S Chen, D E Hillman
Feb 1, 1988·Trends in Neurosciences·C G Jennings
Sep 15, 1998·Trends in Neurosciences·D Goldowitz, K Hamre
Sep 28, 1998·The European Journal of Neuroscience·R HawkesS S Tan
Jan 1, 1992·The European Journal of Neuroscience·F. FredericJ. Mariani
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary Ann CheathamPeter Dallos
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·C BarlowA Wynshaw-Boris
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T A Ralcewicz, T V Persaud
Jan 18, 2006·Brain Research·Michael W VogelJean Mariani
Nov 23, 2006·Brain Research Bulletin·Sabine FrischmuthJörg Bäurle
Jul 6, 2004·The Journal of Comparative Neurology·Hadi ZanjaniJean Mariani
Apr 20, 2007·Developmental Neurobiology·S HeitzY Bailly
Oct 21, 1996·The Journal of Comparative Neurology·H S ZanjaniJ Mariani
Jan 22, 1989·The Journal of Comparative Neurology·J A HeckrothL M Eisenman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.