Abstract
Recent quantitative studies of lurcher chimeric mice have shown that the adult population of cerebellar Purkinje cells can properly be described as a small number of developmental clones of cells. The clones are not seen as patches of contiguous neurons; rather, the cells of any one clone distribute throughout the half-cerebellum that contains them, intermingling extensively with the Purkinje cells of other linkages. Lurcher----wild-type chimeras were analyzed using the cell autonomous Purkinje-cell-lethal mutant, lurcher (+/Lc), as a cell marker. Cell counts from these chimeras revealed that the number of surviving Purkinje cells was always an integral multiple of a unit clone size. These numerical quanta are the evidence for the existence of Purkinje cell developmental clones. When two different inbred strains of mouse were compared (C3H/HeJ and C57BL/6), the resulting clonal analysis showed that the unit clone size (i.e., the number of Purkinje cells in one quantum) is an autonomous property of the lineage and hence, presumably, intrinsic to the progenitor cell that founded it. The current study uses the lurcher chimeric mouse system to examine the cell lineage relationships among the Purkinje cells of a third inbred strain ...Continue Reading
References
Oct 11, 1979·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K W Caddy, T J Biscoe
Nov 17, 1977·Nature·R J Mullen
Jun 1, 1976·Journal of Neurocytology·I A Hendry
Jun 27, 1975·Brain Research·K W Caddy, T J Biscoe
Jan 1, 1976·Journal of Neuropathology and Experimental Neurology·D B Wilson
Jan 1, 1985·Annual Review of Neuroscience·M Jacobson
Jul 4, 1986·Cell·P Soriano, R Jaenisch
May 1, 1986·Developmental Biology·K Herrup
Nov 14, 1985·Nature·R Jaenisch
Mar 29, 1974·Brain Research·D B Wilson
Oct 1, 1971·The Journal of Experimental Zoology·R J Mullen, W K Whitten
Jul 1, 1965·The Journal of Cell Biology·M Atlas, V P Bond
Mar 1, 1984·Developmental Biology·M Jacobson
Dec 1, 1984·Developmental Biology·F RiegerI Tretjakoff
Dec 1, 1984·Journal of Neurogenetics·K HerrupT J Diglio
Dec 1, 1983·Nature·R L Gimlich, J Cooke
Jun 1, 1984·Developmental Biology·K HerrupA Letsou
Jul 15, 1981·Developmental Biology·M L Oster-Granite, J Gearhart
Nov 4, 1982·Brain Research·R Wetts, K Herrup
Oct 1, 1981·Brain Research·D B Wilson
Jun 3, 1961·Nature·A K TARKOWSKI
May 28, 1965·Science·B MINTZ
Oct 1, 1961·Experimental Neurology·I L MIALE, R L SIDMAN
Citations
Jan 22, 1996·The Journal of Comparative Neurology·J A Napieralski, L M Eisenman
Oct 25, 2008·The Cerebellum·Mariaelena RepiciJean Mariani
Jul 1, 1992·Developmental Biology·T S Musci, R J Mullen
Jan 1, 1989·Brain Research. Developmental Brain Research·S Chen, D E Hillman
Feb 1, 1988·Trends in Neurosciences·C G Jennings
Sep 15, 1998·Trends in Neurosciences·D Goldowitz, K Hamre
Sep 28, 1998·The European Journal of Neuroscience·R HawkesS S Tan
Jan 1, 1992·The European Journal of Neuroscience·F. FredericJ. Mariani
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary Ann CheathamPeter Dallos
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·C BarlowA Wynshaw-Boris
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T A Ralcewicz, T V Persaud
Nov 27, 2015·The Cerebellum·Hadi S ZanjaniJean Mariani
Sep 5, 1998·Neuron·S S TanB Faulkner-Jones
Jan 18, 2006·Brain Research·Michael W VogelJean Mariani
Nov 23, 2006·Brain Research Bulletin·Sabine FrischmuthJörg Bäurle
Jul 6, 2004·The Journal of Comparative Neurology·Hadi ZanjaniJean Mariani
Dec 19, 2007·Developmental Neurobiology·S HeitzY Bailly
Apr 20, 2007·Developmental Neurobiology·S HeitzY Bailly
Oct 21, 1996·The Journal of Comparative Neurology·H S ZanjaniJ Mariani
Jul 1, 1988·Neuron·C Cepko
Jan 22, 1989·The Journal of Comparative Neurology·J A HeckrothL M Eisenman