PMID: 7520272Jun 1, 1994Paper

Cell lineage involvement of recurrent chromosomal abnormalities in hematologic neoplasms

Genes, Chromosomes & Cancer
S KnuutilaR Winqvist

Abstract

Analysis of most hematologic neoplasms indicates the involvement of one or more cell lineages in the bone marrow and/or the blood but rules out the involvement of all lineages in any one neoplasm. It is important to detect lineage involvement in order to clarify which stem cells are involved in leukemia, to predict prognosis, and to select appropriate treatment. Our aim was to study the cell lineage involvement of some of the recurrent chromosomal abnormalities seen in hematological neoplasms. The direct morphology-antibody-chromosomes (MAC) method was used. The deletion 20q in myeloproliferative diseases (MPD), the deletion of 5q and t(1;7) in myelodysplastic syndromes (MDS), and t(3;3) in acute myeloid leukemia subtype M7 (AML-M7) were seen in all or at least in two myeloid lineages. These were interpreted as stem cell abnormalities. Deletion 13q in MPD, t(8;21) in AML-M2 and t(15;17) in AML-M3 were seen in granulocytic lineages only; t(14;18) in non-Hodgkin's lymphoma and trisomy 12 as the sole abnormality in chronic lymphocytic leukemia (B-CLL) were seen only in immunoglobulin light chain clonal B cells; inversion 14 in T-CLL was seen only in T cells, whereas t(15;14) in acute lymphocytic leukemia with eosinophilia (ALL-EO)...Continue Reading

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Citations

May 29, 2003·Leukemia & Lymphoma·Takashi Shimamoto, Kazuma Ohyashiki
Sep 3, 2003·European Journal of Haematology·Are P NormannGeir E Tjønnfjord
Aug 19, 2011·British Journal of Haematology·Tim RippergerDoris Steinemann
Jul 5, 2005·Cancer Genetics and Cytogenetics·Jana BrezinováKyra Michalová
Jan 1, 1998·Hematology·D J Culligan
Jul 13, 2012·Current Protocols in Human Genetics·Sakari Knuutila, Satu Mustjoki
Feb 7, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elizabeth MargolskeeAttilio Orazi
Jan 23, 2004·Leukemia·D Grimwade, T Enver
Apr 23, 2008·Current Protocols in Human Genetics·Sakari Knuutila
Nov 1, 1994·European Journal of Haematology·W el-RifaiS Knuutila

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