PMID: 6963887Jan 1, 1982Paper

Cell-mediated and humoral immune responses of guinea-pigs to the oral bacterium Actinomyces viscosus

Archives of Oral Biology
N Doroszczak, P Chen

Abstract

Actinomyces viscosus is a Gram-positive facultative rod indigenous to most human mouths. The guinea-pig was evaluated as a model for assessing cellular immune responses to a human strain of A. viscosus. Guinea-pigs, immunized with heat-killed A. viscosus cells or a water-soluble extract from A. viscosus (AVS), were tested for delayed-type hypersensitivity responses to A. viscosus 4 weeks after immunization. A week later, the guinea-pigs were terminated. Lymphocytes from peripheral blood, lymph node and spleen were tested for in-vitro blastogenic responses to heat-killed A. viscosus or the water-soluble extract. Plasma from these guinea-pigs were tested for the presence of precipitating antibodies. Positive in-vivo delayed-type hypersensitivity reactions and antibody responses to AVS occurred only in immunized guinea-pigs. A strong in-vitro blastogenic response to AVS or heat-killed A. viscosus occurred in lymphocytes from immunized guinea-pigs, but a weak response was detected in un-immunized animals. These data suggest that the guinea-pig can be used to evaluate different parameters of the immune response to oral bacteria such as A. viscosus.

References

Sep 1, 1977·Journal of Periodontology·S S Socransky
Aug 1, 1976·Infection and Immunity·D W TurnerR W Longton
Apr 1, 1975·Archives of Oral Biology·H OkadaM Aono
Oct 1, 1975·Journal of Clinical Microbiology·R P Ellen, I B Balcerzak-Raczkowski
Jan 1, 1972·Journal of Periodontal Research·H V JordanS Bellack
Mar 1, 1972·Koku Eisei Gakkai zasshi·P A Mashimo, S A Ellison
Nov 1, 1974·Journal of Periodontology·R D KigerH R Creamer
May 1, 1969·The Journal of the American Dental Association·R J GencoS A Ellison
Jul 1, 1980·Clinical Immunology and Immunopathology·S SmithJ G Tew

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