Cell-mediated autoimmune response to testis induced by bilateral testicular injury can be suppressed by cyclosporin A

The Journal of Urology
Y SakamotoJ Kumazawa

Abstract

Since the delayed type hypersensitivity (DTH) response to testis antigens plays a key role in the induction and/or maintenance of experimental autoimmune orchitis (EAO), an animal model for human immunological male infertility or aspermatogenesis, we have investigated the immunosuppressive effect of cyclosporin A (CsA) on the DTH response to autologous testicular cells (TC). A DTH response to autologous TC was induced in C3H/HeN mice by bilateral testicular injury (trauma). CsA was administered intraperitoneally for 10 consecutive days before and after injury. A DTH response was assessed by measuring delayed footpad reaction (DFR) to autologous TC 9 days after injury. When the mice were traumatized alone, 10 mg./kg. or more of CsA suppressed the DTH response to autologous TC significantly. In mice traumatized with 100 mg./kg. of cyclophosphamide (CY)-pretreatment, 30 mg./kg. or more of CsA was needed to suppress the DTH response. In mice traumatized with 200 mg./kg. of CY-pretreatment, 50 mg./kg. of CsA was needed to suppress the autoimmune response. The DTH response to autologous TC was suppressed significantly by administration of CsA in a dose-dependent manner. We have also shown the direct suppressive effect of CsA on effec...Continue Reading

References

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Apr 1, 1995·The Journal of Urology·Y SakamotoJ Kumazawa

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Citations

Sep 28, 2002·Urology·M SrinivasS N Das
Oct 11, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Grunewald, U Paasch
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Takeshi Shin, Hiroshi Okada
Feb 19, 2009·The American Journal of Gastroenterology·Linda A Feagins, Sunanda V Kane
May 20, 2006·Annales D'urologie·T Culty, V Ravery

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