PMID: 6967856Jan 1, 1980Paper

Cell-mediated cytotoxicity against HLA-D-region products expressed in monocytes and B lymphocytes. II. HLA-A- or B-antigen compatibility is not required for HLA-D-region directed cytotoxicity

Immunogenetics
C F Feighery, P Stastny

Abstract

When effector cells were produced by sensitization in vitro with HLA-A- and B-compatible but HLA-D/DR-incompatible stimulator cells, cytotoxicity apparently was directed against a product of genes closely associated with HLA-D. For effective killing to occur with effector cells against certain minor histocompatibility antigens it is necessary that the effector cells and the target cells be matched for HLA-A or B. We have, therefore, investigated whether sharing of HLA-A or B antigens is needed to obtain efficient lysis with effector cells primed against HLA-D. Good killing was observed with effector cells against HLA-D/DRw3 and against HLA-D/DRw4 whether or not the HLA-A or B antigens were matched. The results indicated that compatibility at HLA-A or B is not required for cell-mediated cytotoxicity against a product of the HLA-D region. The HLA-D region appears to code for products that behave as strong histocompatibility antigens that can by themselves cause cell-mediated killing.

References

Feb 1, 1979·The Journal of Experimental Medicine·C Feighery, P Stastny
Apr 15, 1978·Lancet·D AlbrechtsenE Thorsby
Apr 20, 1978·The New England Journal of Medicine·P Stastny
Apr 7, 1977·Nature·E GoulmyJ J van Rood
Feb 1, 1979·Transplantation·M JonkerJ J van Rood
Aug 5, 1976·The New England Journal of Medicine·R B EttengerR N Fine
May 1, 1976·The Journal of Clinical Investigation·P Stastny

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