Cell-mediated cytotoxicity toward measles virus-infected target cells in randomly bred Syrian hamsters.

Infection and Immunity
N E CremerJ Diggs

Abstract

Cell-mediated cytotoxicity (CMC) toward measles virus-infected cells was studied by a (51)Cr release assay with spleen cells from hamsters inoculated with measles virus (strain Lec) or control antigen and with spleen cells from normal hamsters. Spleen cells from measles virus-inoculated hamsters showed greater CMC toward infected than toward noninfected target cells (designated specific CMC). Specific CMC was maximal 7 days after virus inoculation and was declining by 9 to 10 days. Effector cells were present in a nonadherent cell population. Specific CMC was reduced after treatments of effector cells with antithymocyte serum plus complement. The decrease in cytotoxicity was greater toward infected target cells than toward noninfected target cells. Treatment of infected target cells with antimeasles serum did not increase specific CMC by effector cells from the majority of virus-inoculated hamsters. CMC toward infected target cells by normal spleen cells (natural killer cells) or spleen cells from hamsters inoculated with control antigen was approximately the same as, or more often less than, CMC toward noninfected target cells. Natural killer cells were present in a nonadherent cell population. Treatment of natural killer cell...Continue Reading

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