PMID: 6980843Jan 1, 1982Paper

Cell-mediated effector mechanisms in aging humans

International Archives of Allergy and Applied Immunology
N B MarcanoN E Bianco

Abstract

Specific and nonspecific cell-mediated effector mechanisms have been simultaneously assayed in 15 aged humans. 8 were female and 7 male, including a 114-year-old male in remarkably good health. Proliferative response to alloantigens, the generation of T killer cells and the ability to express cell-mediated lympholysis as well as the presence of natural cell-mediated cytotoxicity against K562 tumor cell line and the capacity to mount an ADCC response to RhD+ human red blood cell sensitized with anti-D antisera, revealed that in the human aged, while T function significantly declines, nonspecific cell-mediated effector mechanisms are operative.

Citations

Jun 1, 1997·Mechanisms of Ageing and Development·R Krishnaraj
Apr 1, 1984·Journal of the American Geriatrics Society·J S ThompsonN Tietz
Jan 1, 1988·Annals of the New York Academy of Sciences·G F SolomonT Makinodan
Feb 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·H NielsenS O Larsen

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