PMID: 8952852Jan 1, 1996Paper

Cell-mediated immunity in breast cancer patients

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
A NicoliniF Ambrogi

Abstract

In clinical practice, reports have been made on immunosuppression after surgical excision of primary tumor or at relapse. However, the relationship between undefined or overt metastases and the host immune system has not been sufficiently examined over a prolonged period. These aspects were investigated in 160 breast cancer patients followed up post-operatively with serial controls over a long period. One hundred and thirty-four cases (91 node negative, (N-), 43 node positive (N+)) were disease-free and 26 relapsed. In all patients, serum T cell populations, serum B lymphocytes and skin reaction of delayed hypersensitivity (SRDH) were serially determined for 39 +/- 12 months (m +/- SD). The reference values for these parameters were assessed as follows: T populations were evaluated in 24 healthy donors and SRDH in 95 healthy females. In non-relapsed patients, constant CD8+ T cell decrease and T4/T8 ratio increase were observed; the T4/T8 ratio was significantly higher (ranging from P < 0.05 - P < 0.001) than in the control group. The mean values of NK cells and B lymphocytes, the former parameter being highly significant (P < 0.001), were higher than in controls. In the 26 metastatic patients, the T4/T8 ratio from 20 months bef...Continue Reading

Citations

Jun 15, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christina LindemalmHåkan Mellstedt
May 4, 2005·Breast Cancer Research and Treatment·Michael J CampbellLaura J Esserman
Nov 7, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A NicoliniR Giardino
Aug 13, 1999·Breast Cancer Research and Treatment·L S GutierrezG Mor
May 6, 2004·The Breast Journal·Jane S Blake-MortimerDavid Spiegel
Oct 20, 2009·Journal of Psychosomatic Research·Bonnie B BlombergMichael H Antoni
Dec 22, 2006·Respiratory Medicine·Marios E FroudarakisPhilippe Astoul
Aug 18, 2006·Journal of Medical Microbiology·Yasuaki ArataniHideki Koyama
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaohua YuHuang-Ge Zhang

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