PMID: 640742Jan 1, 1978Paper

Cell-mediated immunity in the lungs of rabbits using conjugated proteins

International Archives of Allergy and Applied Immunology
V L MooreJ O Stevens

Abstract

A study using direct macrophage migration inhibition of cells from the lower respiratory tract of rabbits immunized with conjugated proteins, incorporated into a killed BCG-oil emulsion, revealed that the reaction was largely carrier specific. The only exception was when bronchoalveolar cells (BAC) from animals immunized with dinitrophenol coupled to ovalbumin (DNP-OA) were significantly immobilized with DNP coupled to bovine gamma-globulin (BGG) in which the ratio of DNP/BGG was high [DNP-BGG(H)]. This result could not be explained by a toxic effect or by a high net negative charge on DNP-BGG(H). In addition, inhibition of BAC from DNP-OA-immunized rabbits was not observed when the ratio of DNP to BGG was reduced approximately 5-fold.

Citations

Jan 1, 1979·Vox Sanguinis·K E HopperD S Nelson

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