Cell-mediated immunity to herpes simplex virus: specificity of cytotoxic T cells.

Infection and Immunity
M J LawmanB T Rouse

Abstract

This communication deals with the question of which of the viral antigens constitutes the targets for cytotoxic T lymphocytes (CTL) generated against herpes simplex virus type 1 (HSV-1). The approach used was, first, to compare cytotoxicity of CTL against target cells infected with virus in the presence of tunicamycin and 2-deoxy-D-glucose, which are known to inhibit glycoprotein synthesis, and second, to compare cytotoxicity of CTL against target cells infected with wild-type HSV-1 with that against target cells infected with a temperature-sensitive mutant of HSV-1 which, at the nonpermissive temperature, exhibits diminished glycoprotein synthesis. The results show that glycoprotein expression is required for the demonstration of cytotoxic activity of CTL. The level of cytotoxicity against the temperature-sensitive HSV-1 target at the nonpermissive temperature was reduced and correlated with the level of expression of the major envelope glycoprotein region (VP123; molecular weight = 123,000) at the target cell surface as measured serologically by antibody binding studies. The results were interpreted to indicate that HSV-1-induced glycoproteins are the target antigens for anti-HSV CTL and that the principal viral antigens reco...Continue Reading

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A H HaleH N Eisen
Sep 1, 1977·The Journal of Experimental Medicine·F A EnnisM W Verbonitz
Jan 1, 1974·Advances in Immunology·J C Cerottini, K T Brunner
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Jan 1, 1980·Infection and Immunity·M J LawmanR D Walker

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Citations

Nov 1, 1988·Journal of Virology·D R FitzpatrickM J Lawman
Jan 1, 1988·Annals of the New York Academy of Sciences·S MartinB T Rouse
Jul 1, 1992·Research in Virology·J C BowenM R Brown
Apr 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·I DavidsonM Malkinson

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