Cell-mediated immunity to mycobacteria: a double-sided sword?

Rheumatology International
S H KaufmannT Koga

Abstract

Mycobacteria are intracellular pathogens capable of replicating in resting macrophages. Specific helper T lymphocytes which activate antimycobacterial capacities in infected macrophages represent an important constituent of acquired resistance. In addition, cytolytic T lymphocytes may contribute to resistance. On the other hand, lysis of infected host cells may also comprise autoaggressive consequences. Recent evidence suggest that T cells with specificity for mycobacterial heat shock proteins are involved in the antimycobacterial immune response. Heat shock proteins are evolutionarily highly conserved and cross-reactivity between microbial and mammalian molecules may occur on the B-cell and T-cell level. Thus, T cells directed against shared epitopes of mycobacterial and autologous origin could initiate autoimmune reactions.

References

Jan 1, 1988·European Journal of Immunology·G De LiberoS H Kaufmann
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Jun 1, 1988·The Journal of Experimental Medicine·F R CarboneM J Bevan
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Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D YoungR A Young
Jun 1, 1988·Immunology Today·S H Kaufmann
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Nov 1, 1981·Reviews of Infectious Diseases·H Hahn, S H Kaufmann
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