Cell-mediated immunity to the asexual blood stages of malarial parasites: animal models

Immunology Letters
W P WeidanzL A Cavacini

Abstract

Studies using experimental models of malaria in immunodeficient mice and chickens have shown that resistance to blood-stage infection is mediated by protective antibodies and T cell-dependent cell-mediated mechanisms of immunity. Depending on the infecting species of Plasmodium and prior experience of the host, either humoral or cell-mediated immune mechanisms predominate. Cell-mediated immunity has been adoptively transferred with CD4+ splenic T cells, and with antigen-specific T cell lines and clones. Since ascending parasitemia occurs in all instances, the transferred cells do not kill plasmodia directly but appear to activate effector mechanisms capable of destroying the invading parasites. Both CD4+ and CD8+ T cells were found to increase in the spleens of malarious mice. Depletion of CD4+ T cells prevented nude mice adoptively transferred with immune splenic T cells from clearing parasitemia. In contrast, late treatment with anti-CD4 antibody had little if any effect. The converse was true when anti-CD8 antibody was utilized, i.e., a significant number of mice treated with anti-CD8 antibody after parasitemia became patent and had difficulty clearing blood parasites. These data suggest that during infection CD8+ T cells ma...Continue Reading

References

Jan 15, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S Cohen
Nov 13, 1975·Nature·A N JayawardenaA J Davies
Aug 1, 1990·Immunology Letters·M HoW P Weidanz
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M LewM Sheppard
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R WeissM F Good
Jul 20, 1968·Nature·I N BrownR B Taylor
Jan 1, 1980·Infection·R KretschmerS P Gotoff

❮ Previous
Next ❯

Citations

May 3, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ahmad Kashfi Ab Rahman, Fatimah Haslina Abdullah
Jun 30, 2007·The American Journal of Pathology·Fiona H AmanteChristian R Engwerda
Mar 29, 2013·Scientific Reports·Takashi ImaiHajime Hisaeda
Jun 17, 2019·Parasites & Vectors·Mebrahtu G TedlaJean-Pierre Y Scheerlinck
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saskia deWalickChristian R Engwerda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.