PMID: 6168591Jan 1, 1981Paper

Cell-mediated suppression of tumor immunity has a non-specific component. I. Evidence from transplantation tests

International Journal of Cancer. Journal International Du Cancer
K E Hellström, I Hellström

Abstract

We have first demonstrated that the growth of a transplanted, 3-methyl-cholanthrene-induced BALB/c sarcoma, MCA-1425, in specifically immune syngeneic mice, was facilitated when the MCA-1425 tumor cells were injected together with either a mixture of irradiated MCA-1425 cells and thymus cells from mice immune to MCA-1425 or a mixture of irradiated cells from an antigenically different BALB/c sarcoma, MCA-1460, and thymus cells from mice immune to MCA-1460. We then performed Winn assays to study the induction of an immune response that could prevent the outgrowth of MCA-1425 cells in irradiated syngeneic recipients. Tumor immunity was found to be suppressed, if the mice immunized by a subcutaneous transplant of MCA-1425 cells and used as lymphocyte donors, were injected intraperitoneally with cells from either a different sarcoma, MCA-1460, or from 12-day BALB/c embryos. We tentatively attribute our finding to antigen-non-specific suppressor effector cells and postulate that an antigen-specific event is often involved in their induction.

References

Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·K E HellströmJ P Brown
Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·I HellströmJ P Brown
Jan 1, 1977·Contemporary Topics in Immunobiology·C S Henney
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P BrownK E Hellström
Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·S B HowellL W Law
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M I GreeneB Benacerraf
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K E Hellström, I Hellström
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Jun 1, 1977·Cellular Immunology·R A Daynes, C W Spellman
Jan 1, 1973·Advances in Cancer Research·R W Baldwin

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Citations

Mar 15, 1983·Experientia·G T NepomK E Hellström
Jan 1, 1981·International Journal of Cancer. Journal International Du Cancer·I Hellström, K E Hellström
Feb 26, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Karl Erik Hellstrom, Ingegerd Hellstrom
Aug 1, 1987·Immunology and Cell Biology·D S Nelson, M Nelson

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