PMID: 6168592Jan 1, 1981Paper

Cell-mediated suppression of tumor immunity has a non-specific component. II. Evidence from cell culture experiments

International Journal of Cancer. Journal International Du Cancer
I Hellström, K E Hellström

Abstract

In vitro studies were performed to search for cells in the thymus of BALB/c mice with MCA-induced sarcomas which could suppress either a secondary immune response to MuLV-associated tumor antigens present on a Moloney leukemia virus-induced lymphoma, LSTRA, or a primary cytotoxic response to C57BL/6 alloantigens. They showed that thymocytes from mice with sarcomas were suppressive in both systems, and that suppression was independent of whether or not the sarcomas expressed MuLV antigen gp70. Furthermore, normal thymocytes, when combined with mitomycin-C-treated cells from any of several different MCA-induced sarcomas, suppressed the in vitro generation of a secondary cytolytic response to LSTRA. We postulate that exposure of mice to certain tumor antigens induces cells which, in the presence of the same tumor antigens which are not detectably present on the tumor cells inducing the response.

References

Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·K E HellströmJ P Brown
Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·I HellströmJ P Brown
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P BrownK E Hellström
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1981·International Journal of Cancer. Journal International Du Cancer·K E Hellström, I Hellström

❮ Previous
Next ❯

Citations

May 9, 1983·Life Sciences·J E MorleyN E Rowland
Aug 1, 1987·Immunology and Cell Biology·D S Nelson, M Nelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.