Cell membrane damage induced by lacticin 3147 enhances aldehyde formation in Lactococcus lactis IFPL730

International Journal of Food Microbiology
M Carmen Martínez-CuestaCarmen Peláez

Abstract

Amino acid catabolism is mainly initiated in Lactococcus lactis by a transamination reaction that leads to the formation of alpha-keto acids. In addition, a novel alpha-keto acid decarboxylase enzyme, rare in lactic acid bacteria, responsible for the conversion of alpha-keto acids into aldehydes has been reported in L. lactis IFPL730. The effect of lacticin 3147-induced cell damage on both amino acid transamination and alpha-keto acid decarboxylation by L. lactis IFPL730 leading to the formation of aldehydes from amino acids was investigated. Cell membrane permeabilization induced by lacticin 3147 facilitated the diffusion of amino acids into the cells and thus, enhanced amino acid transamination and formation of alpha-keto acids. However, alpha-keto acid decarboxylation was not affected by cell membrane permeabilization since decarboxylation of alpha-keto acids in both control and lacticin 3147-treated cells were similar, suggesting that these substrates could freely diffuse inside the cells. Nevertheless, the formation of 2-methylbutyraldehyde from isoleucine was enhanced in lacticin 3147-treated cells. The increase in alpha-keto acids formation rate by L. lactis IFPL730 due to lacticin 3147-induced cell damage, led to a conc...Continue Reading

References

Aug 5, 2000·Applied and Environmental Microbiology·M C Martínez-CuestaG Buist
Sep 6, 2000·Journal of Applied Microbiology·M C Martínez-CuestaT Requena
Apr 25, 2001·Applied and Environmental Microbiology·C J BunthofT Abee
Aug 30, 2001·Applied and Environmental Microbiology·C J BunthofJ Hugenholtz
Oct 30, 2001·FEMS Microbiology Letters·F AmáritaC Pelaez
May 28, 2004·International Journal of Food Microbiology·Pilar Fernández de PalenciaCarmen Peláez

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Citations

Oct 15, 2008·Applied Microbiology and Biotechnology·O GillorM A Riley
Nov 19, 2008·Applied Microbiology and Biotechnology·Bart A SmitGerrit Smit
Aug 11, 2006·Biotechnology Letters·M Carmen Martínez-CuestaCarmen Peláez
Jun 24, 2008·Critical Reviews in Biotechnology·Antonio GalvezNabil Ben Omar
Oct 30, 2016·Critical Reviews in Food Science and Nutrition·Muhammad Inam AfzalCatherine Cailliez-Grimal
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Silpa S, Rupachandra S

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