Cell membrane-formed nanovesicles for disease-targeted delivery

Journal of Controlled Release : Official Journal of the Controlled Release Society
Jin GaoZhenjia Wang

Abstract

Vascular inflammation is the underlying component of most diseases. To target inflamed vasculature, nanoparticles are commonly engineered by conjugating antibody to the nanoparticle surface, but this bottom-up approach could affect nanoparticle targeting and therapeutic efficacy in complex, physiologically related systems. During vascular inflammation endothelium via the NF-κB pathway instantly upregulates intercellular adhesion molecule 1 (ICAM-1) which binds integrin β2 on neutrophil membrane. Inspired by this interaction, we created a nanovesicle-based drug delivery system using nitrogen cavitation which rapidly disrupts activated neutrophils to make cell membrane nanovesicles. Studies using intravital microscopy of live mouse cremaster venules showed that these vesicles can selectively bind inflamed vasculature because they possess intact targeting molecules of integrin β2. Administering of nanovesicles loaded with TPCA-1 (a NF-κB inhibitor) markedly mitigated mouse acute lung inflammation. Our studies reveal a new top-down strategy for directly employing a diseased tissue to produce biofunctional nanovesicle-based drug delivery systems potentially applied to treat various diseases.

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Citations

Mar 19, 2016·Advanced Healthcare Materials·Dafeng ChuZhenjia Wang
Mar 27, 2018·Advanced Materials·Dafeng ChuZhenjia Wang
Feb 28, 2018·The AAPS Journal·Sihan WangZhenjia Wang
Dec 9, 2017·Therapeutic Delivery·Xinyue DongZhenjia Wang
Apr 28, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sihan WangZhenjia Wang
Sep 12, 2018·Advanced Materials·Can Yang ZhangZhenjia Wang
Mar 9, 2020·Analytical and Bioanalytical Chemistry·Xu FuChristopher I Richards
Jun 2, 2020·Chemical Communications : Chem Comm·Zhijie ZhangZifu Li
Aug 28, 2020·Frontiers in Immunology·Jackline Joy Martín LasolaRyan M Pearson
May 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xutong ShiZhenjia Wang
Jul 25, 2019·Frontiers in Pharmacology·Guoyu YangJianxiang Zhang
Oct 13, 2020·Critical Reviews in Microbiology·Roghayeh MohammadzadehSaman Soleimanpour
Oct 18, 2020·International Journal of Molecular Sciences·Xinyue DongZhenjia Wang
Oct 19, 2019·Methods : a Companion to Methods in Enzymology·Hyejin KimJong Bum Lee
Nov 16, 2020·Biomaterials·Peipei WuHui Qian
Dec 4, 2019·Methods : a Companion to Methods in Enzymology·Jin GaoZhenjia Wang
Dec 15, 2020·Advanced Therapeutics·Xinyue DongZhenjia Wang
Apr 17, 2020·Journal of Drug Targeting·Mingliang Fan, Minxing Jiang
Mar 16, 2017·Biomaterials·Ronnie H FangLiangfang Zhang
Mar 30, 2021·International Journal of Nanomedicine·Shuai BianChunsheng Xiao
Mar 30, 2021·Bioactive Materials·Pallabita ChowdhuryMurali M Yallapu
Mar 30, 2021·Advanced Drug Delivery Reviews·Mina MehannyGregor Fuhrmann
May 6, 2021·Free Radical Biology & Medicine·Nan YangMing-Lin Liu
Jun 9, 2021·Signal Transduction and Targeted Therapy·Li ChenZhiyao He
Jul 19, 2021·Tissue Engineering and Regenerative Medicine·Juhee HahmJongmin Park
Aug 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuo WangYihui Deng
Aug 14, 2021·Journal of Nanobiotechnology·Yong-Jiang LiDa-Xiong Xiang
Aug 29, 2019·ACS Omega·Aaron A SnellChristopher I Richards
Apr 12, 2019·ACS Applied Materials & Interfaces·Can Yang ZhangZhenjia Wang

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