Cell membrane water exchange effects in prostate DCE-MRI.

Journal of Magnetic Resonance
Xin LiC S Springer

Abstract

Prostate Dynamic-Contrast-Enhanced (DCE) MRI often exhibits fast and extensive global contrast reagent (CR) extravasation - measured by K(trans), a pharmacokinetic parameter proportional to its rate. This implies that the CR concentration [CR] is high in the extracellular, extravascular space (EES) during a large portion of the DCE-MRI study. Since CR is detected indirectly, through water proton signal change, the effects of equilibrium transcytolemmal water exchange may be significant in the data and thus should be admitted in DCE-MRI pharmacokinetic modeling. The implications for parameter values were investigated through simulations, and analyses of actual prostate data, with different models. Model parameter correlation and precision were also explored. A near-optimal version of the exchange-sensitized model was found. Our results indicate that ΔK(trans) (the K(trans) difference returned by this version and a model assuming exchange to be effectively infinitely fast) may be a very useful biomarker for discriminating malignant from benign prostate tissue. Using an exchange-sensitized model, we find that the mean intracellular water lifetime (τ(i)) - an exchange measure - can be meaningfully mapped for the prostate. Our resul...Continue Reading

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Citations

Dec 5, 2014·Medical Physics·Fahmi KhalifaAmy C Dwyer
Mar 30, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xin LiCharles S Springer
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jin Zhang, Sungheon Kim
May 7, 2014·NMR in Biomedicine·Charles S SpringerWei Huang
Jul 24, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tammo RukatStefan A Reinsberg
Apr 29, 2015·NMR in Biomedicine·William D RooneyCharles S Springer
Dec 21, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gregory J WilsonJeffrey H Maki
Apr 16, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Stephen PatrickKevin M Brindle
Jun 12, 2016·Journal of Magnetic Resonance·Xin LiCharles S Springer
Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Ruiliang BaiYingchao Liu
Mar 25, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xin LiCharles S Springer
Dec 30, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Xueyan ZhouGregory S Karczmar
Sep 21, 2021·Tissue Barriers·Valerie C AndersonWilliam D Rooney

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