Cell migration capability of vascular endothelial growth factor into the root apex of a root canal model in vivo

Journal of Oral Science
Takashi MatsuuraYoshihiko Hayashi

Abstract

Once a tooth develops deep caries and the dental pulp tissue is irreversibly infected, the infected dental pulp tissue should be removed, and filling material should be placed in the root canal. Endodontically treated teeth are prone to root fracture or periapical periodontitis; however, dental pulp tissue has the potential to prevent root fracture or periapical periodontitis. Therefore, dental pulp regeneration after pulpectomy may help prolong tooth life. In this study, a new method of dental pulp regeneration was developed. Vascular endothelial growth factor-adsorbed collagen gel was injected into the root canal of a prepared root canal model, placed into the dorsum of a rat, and cultured for 3 weeks. After retrieving the implant, histological analysis was performed. It was found that rat somatic cells were recruited into the root apex of the transplanted root canal model. These findings suggest a new potential technique for engineering dental pulp tissue.

References

Nov 11, 2003·Journal of Endodontics·Till DammaschkeKlaus Heinrich Reiner Ott
Feb 26, 2008·Cell·Diana J LairdAmy J Wagers
May 8, 2010·Journal of Dental Research·K KimJ J Mao
May 22, 2010·Tissue Engineering. Part a·Jin Y KimJeremy J Mao
Apr 5, 2014·Journal of Endodontics·Misako Nakashima, Koichiro Iohara
Sep 23, 2014·Clinical Science·Alexander BirbrairOsvaldo Delbono

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