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Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Aug 19, 2019

Marina KrauseKatarina Wolf

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Abstract

Directional cell migration in dense three-dimensional (3D) environments critically depends upon shape adaptation and is impeded depending on the size and rigidity of the nucleus. Accordingly, the nucleus is primarily understood as a physical obstacle; however, its pro-migratory function...read more

Mentioned in this Paper

Malignant Neoplasms
Cell Nucleus
Collagen
Pharmacotherapy
Environment
Microscopy, Fluorescence
Neoplasms
Lamin C
Internal
Microscopy, Atomic Force
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Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Aug 19, 2019

Marina KrauseKatarina Wolf

PMID: 31431171

DOI: 10.1098/rstb.2018.0225

Abstract

Directional cell migration in dense three-dimensional (3D) environments critically depends upon shape adaptation and is impeded depending on the size and rigidity of the nucleus. Accordingly, the nucleus is primarily understood as a physical obstacle; however, its pro-migratory function...read more

Mentioned in this Paper

Malignant Neoplasms
Cell Nucleus
Collagen
Pharmacotherapy
Environment

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