PMID: 2116988Jun 1, 1990Paper

Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus

Genes & Development
S K Kim, D Kaiser

Abstract

There are striking similarities between the developmental phenotypes of two different mutant classes of Myxococcus xanthus. The first class, mglA mutants, are nonmotile under all conditions tested. The second class, csgA mutants, are motile but belong to a class of signal-defective developmental mutants that cannot develop alone but will develop when mixed with intact wild-type cells. Nevertheless, both csgA and mglA mutants fail to aggregate properly or to sporulate when induced to form fruiting bodies. An mglA mutation and a csgA mutation affect expression of a panel of lacZ fusions to developmental genes in the same way, indicating that nonmotile cells and csgA cells arrest development at a similar stage. One explanation for the similarity of developmental phenotypes between these mutants is that motility is required for the csgA-mediated cell interaction. In support of this hypothesis, we report that C-factor, a protein purified from nascent wild-type fruiting bodies based on its ability to rescue csgA mutant fruiting body development, also rescues sporulation and expression of beta-galactosidase from developmentally controlled lacZ fusions in mglA strains, apparently without restoring their motility. Wild-type levels of ac...Continue Reading

References

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May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S K Kim, D Kaiser
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Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L J ShimketsD Kaiser

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Citations

Nov 1, 1995·Archives of Microbiology·P L Hartzell, P Youderian
Nov 11, 2003·Journal of Microbiological Methods·Lars Jelsbak, Lotte Søgaard-Andersen
Dec 21, 2000·Current Opinion in Microbiology·L Jelsbak, L Søgaard-Andersen
Mar 26, 2004·Nature Reviews. Microbiology·Dale Kaiser
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Søgaard-Andersen, D Kaiser
May 5, 2006·Applied and Environmental Microbiology·Michiel Vos, Gregory J Velicer
Dec 26, 2006·Journal of Bacteriology·Thomas M A Gronewold, Dale Kaiser
Apr 27, 2002·Journal of Bacteriology·Gregory J VelicerLee Kroos
Jun 2, 2004·Journal of Molecular Microbiology and Biotechnology·Eric Nudleman, Dale Kaiser
Dec 2, 2011·PloS One·Swapna BhatLawrence J Shimkets
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·P L Hartzell
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Jelsbak, L Søgaard-Andersen
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Oleg A IgoshinGeorge Oster
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haiyu ZhangArthur Kornberg
Nov 1, 1994·Molecular Microbiology·S D MacNeilP L Hartzell
Feb 1, 1995·Molecular Microbiology·K Kashefi, P L Hartzell
Nov 6, 2012·Research in Microbiology·Darshankumar T PathakDaniel Wall
Sep 24, 2004·Trends in Endocrinology and Metabolism : TEM·Ola Nilsson, Jeffrey Baron
Jun 4, 1993·Cell·D Kaiser, R Losick
Oct 1, 1991·Current Opinion in Genetics & Development·H B Kaplan
Dec 21, 2013·FEMS Microbiology Reviews·Anna KonovalovaLee Kroos
Nov 10, 2009·FEMS Microbiology Reviews·Anna KonovalovaLotte Søgaard-Andersen
Oct 19, 2004·Annual Review of Microbiology·Dale Kaiser
Nov 5, 1999·Annual Review of Microbiology·L J Shimkets
Jul 20, 2016·Journal of Molecular Biology·Daniel J Bretl, John R Kirby
Nov 24, 1999·Molecular Microbiology·K Cho, D R Zusman

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