Cell Na and K in the rat tail artery during the development of hypertension induced by desoxycorticosterone acetate.

Proceedings of the Society for Experimental Biology and Medicine
S M FriedmanC L Friedman

Abstract

An increase in total Na, due in large part to an increase in cell Na, was measured in the freshly excised rat tail artery during the course of DOCA-saline treatment. Since this change was associated with a fall in cell K, was first observed at 2 weeks, coincident with the rise in blood pressure, and was not sustained during subsequent immersion of the artery at zero pressure, it probably reflects the high in vivo intravascular pressure. In the incubated artery, cell Na is significantly reduced early in the course of treatment, while cell K falls late. Thus, Na transport in the artery is under direct attack from the start, but it is suggested that this leads to hypertrophy rather than to vasoconstriction.

Citations

Feb 1, 1982·Journal of Steroid Biochemistry·L KornelW J Raynor
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L Kornel
Aug 28, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Young Min BaeSung Il Cho
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·S Manjeet, M K Sim
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·F HaddyD Clough
Jul 1, 1983·Journal of Steroid Biochemistry·L KornelW J Raynor
Jan 1, 1982·Hypertension·H W Overbeck, D E Grissette
May 1, 1990·Hypertension·S M Friedman
Sep 1, 1976·Circulation Research·S M Friedman, C L Friedman
Nov 15, 2000·American Journal of Hypertension·A McLauren DorranceR Fraser

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