PMID: 804353Jan 1, 1975Paper

Cell number and cell density in the cerebellar cortex of man and some other mammals

Cell and Tissue Research
W Lange


The number of cells per unit volume was determined in the cerebellar cortex of man and 19 other mammals. The cell density (i.e. the number of cells per unit volume) decreases from mammals with a low brain weight to those with a higher brain weight. This decrease in the number of cells is found to be proportional for all three layers of the cerebellar cortex. In addition, the ratio of Purkinje cells to granule cells was determined. In contrast to the decrease of all cell types with increasing brain weight, this ratio varies remarkably among the mammals and is not correlated with brain weight. In man, this ratio is 1:2991, while it is lower in all other mammals investigated. These differences in the ratio of Purkinje cells to granule cells and the decrease in cell density with increasing brain weight are discussed in relation to brain evolution.


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