Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging

Journal of the American Chemical Society
Kwangmeyung KimIck Chan Kwon

Abstract

Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.

References

Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BoussifJ P Behr

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Citations

Oct 22, 2010·Journal of Neural Transmission·X ZhangCheng Wang
Dec 13, 2007·Heart Failure Reviews·Ethan Chauncey KorngoldDavid Edwin Sosnovik
May 18, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Helen SuHartmuth C Kolb
Jun 29, 2013·ACS Applied Materials & Interfaces·Yupeng ShiQing Jiang
Mar 9, 2010·Chemical Reviews·Renatus W SinkeldamYitzhak Tor
Sep 14, 2011·Journal of the American Chemical Society·Santimukul SantraJ Manuel Perez
Nov 26, 2009·ACS Nano·David K BwambokIsiah M Warner
Sep 20, 2008·Chemical Communications : Chem Comm·Seulki LeeIck Chan Kwon
Apr 17, 2010·Nanomedicine·Motoi Oishi, Yukio Nagasaki
Nov 3, 2007·Nanomedicine·Eric M PridgenOmid C Farokhzad
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Fu WangXiaoyuan Chen
Feb 1, 2014·Analytical and Bioanalytical Chemistry·Xiangyi HuangJicun Ren
May 23, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Young YheeIck Chan Kwon
Dec 17, 2014·Journal of the National Cancer Institute·Beom Suk LeeSang Yoon Kim
Jan 12, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Ilgım GöktürkAdil Denizli
Nov 20, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Harshita SharmaBhuvaneshwar Vaidya
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei ZhuXiaoyuan Chen
Sep 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kai WangByung-Heon Lee
Apr 23, 2009·Advanced Drug Delivery Reviews·Nobuhiro NishiyamaKazunori Kataoka
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sungwon KimKinam Park
Mar 13, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·R SrikarRaghuraman Kannan
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ashish KulkarniShiladitya Sengupta
Jul 19, 2013·BioMed Research International·Arun SharmaRashmi Sareen
Feb 25, 2015·Nanomedicine·Dusica Maysinger, Eliza Hutter
Jan 19, 2015·Apoptosis : an International Journal on Programmed Cell Death·Min TangYa Cao
Oct 20, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seung-Young LeeIck Chan Kwon
Oct 28, 2016·Neurotoxicology and Teratology·X ZhangM G Paule
Oct 29, 2014·Chemistry : a European Journal·Yosuke NikoAndrey S Klymchenko
Sep 2, 2014·Chemical Society Reviews·Dali WangWenxin Wang
Jun 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Bing LiPengfei Yan
Dec 2, 2017·Scientific Reports·Man Kyu ShimKwangmeyung Kim
Mar 3, 2018·Chemical Society Reviews·Pengcheng ZhangHonggang Cui
Sep 15, 2006·Chembiochem : a European Journal of Chemical Biology·Elena A GounPaul A Wender

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