Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1

Journal of Neurophysiology
Eric Klann

Abstract

Long-term potentiation (LTP) in hippocampal area CA1 is generally dependent on N-methyl--aspartate (NMDA) receptor activation. Reactive oxygen species (ROS), including superoxide, are produced in response to NMDA receptor activation in a number of brain regions, including the hipppocampus. In this study, two cell-permeable manganese porphyrin compounds that mimic superoxide dismutase (SOD) were used to determine whether production of superoxide is required for the induction of LTP in area CA1 of rat hippocampal slices. Incubation of hippocampal slices with either Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) or Mn(III) tetrakis (1-methyl-4-pyridyl) porphyrin (MnTMPyP) prevented the induction of LTP. Incubation of slices with either light-inactivated MnTBAP or light-inactivated MnTMPyP had no effect on induction of LTP. Neither MnTBAP nor MnTMPyP was able to reverse preestablished LTP. These observations suggest that production of superoxide occurs in response to LTP-inducing stimulation and that superoxide is necessary for the induction of LTP.

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Citations

Jul 19, 2006·Molecular and Cellular Biology·Kenneth T KishidaEric Klann
Nov 23, 2006·Antioxidants & Redox Signaling·Kenneth T Kishida, Eric Klann
May 19, 2010·Journal of Neurochemistry·Romina M UrangaJeffrey N Keller
Jan 15, 2014·Antioxidants & Redox Signaling·Andrea C Paula-LimaCecilia Hidalgo
Apr 8, 2016·Physiology·Cecilia Hidalgo, Alejandra Arias-Cavieres
Jan 13, 2018·FEBS Letters·Matthew C W OswaldMatthias Landgraf
Feb 24, 2001·Annals of the New York Academy of Sciences·J P Blass
Jul 23, 2005·IUBMB Life·Cecilia HidalgoM Angélica Carrasco
Jan 31, 2006·Molecular and Cellular Biochemistry·Recep SutcuNamik Delibas
Jul 24, 2010·Antioxidants & Redox Signaling·Cynthia A Massaad, Eric Klann
Dec 25, 2008·Annals of Neurology·Sang Won SuhRaymond A Swanson
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gang WangVirginia M Pickel
Feb 24, 2018·Frontiers in Aging Neuroscience·Soghra BagheriAli A Saboury
Jun 28, 2019·Journal of Cellular Physiology·Sebastian AbarzúaBrigitte van Zundert
Nov 23, 2006·Antioxidants & Redox Signaling·Daoying HuEdda Thiels
Aug 6, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joseph S TauskelaPaul Morley
Aug 31, 2006·Journal of Neuroscience Research·J B WatsonT J O'Dell
Jul 17, 2004·The European Journal of Neuroscience·Ali Shahraki, Trevor W Stone
Nov 23, 2006·Antioxidants & Redox Signaling·Cecilia HidalgoMarco T Núñez
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Cecilia Hidalgo
Jun 8, 2007·Journal of Neurophysiology·Dominic P D'AgostinoJay B Dean
Feb 16, 2008·Endocrinology·Susan A FarrJohn E Morley
Jun 9, 2009·Nature Neuroscience·Angela M BrennanRaymond A Swanson
Sep 15, 2016·Journal of Experimental Neuroscience·Thiago Fernando BeckhauserRoberto De Pasquale
Jul 22, 2016·Molecular Pharmacology·Daniel J Calvo, Andrea N Beltrán González
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K NiwaC Iadecola
Jul 7, 2005·Journal of Neurochemistry·Kenneth T KishidaEric Klann
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NiwaC Iadecola
Apr 20, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laibaik ParkCostantino Iadecola
Sep 19, 2002·Journal of Neuroscience Research·Lauren T Knapp, Eric Klann

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