Cell polarity and migration: emerging role for the endosomal sorting machinery

Physiology
Viola Hélène Lobert, Harald Stenmark

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery has been implicated in the regulation of endosomal sorting, cell division, viral budding, autophagy, and cell signaling. Here, we review recent evidence that implicates ESCRTs in cell polarity and cell migration, and discuss the potential role of ESCRTs as tumor suppressors.

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Citations

Dec 10, 2013·BMC Genomics·Louise M BrignullAxel Nohturfft
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Dec 19, 2018·Nature Communications·Erin Kate McNally, Christopher Leonard Brett

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