Cell polarity, epithelial-mesenchymal transition, and cell-fate decision gene expression in ductal carcinoma in situ.

International Journal of Surgical Oncology
Danila CoradiniSaro Oriana

Abstract

Loss of epithelial cell identity and acquisition of mesenchymal features are early events in the neoplastic transformation of mammary cells. We investigated the pattern of expression of a selected panel of genes associated with cell polarity and apical junction complex or involved in TGF-β-mediated epithelial-mesenchymal transition and cell-fate decision in a series of DCIS and corresponding patient-matched normal tissue. Additionally, we compared DCIS gene profile with that of atypical ductal hyperplasia (ADH) from the same patient. Statistical analysis identified a "core" of genes differentially expressed in both precursors with respect to the corresponding normal tissue mainly associated with a terminally differentiated luminal estrogen-dependent phenotype, in agreement with the model according to which ER-positive invasive breast cancer derives from ER-positive progenitor cells, and with an autocrine production of estrogens through androgens conversion. Although preliminary, present findings provide transcriptomic confirmation that, at least for the panel of genes considered in present study, ADH and DCIS are part of a tumorigenic multistep process and strongly arise the necessity for the regulation, maybe using aromatase i...Continue Reading

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Citations

Aug 3, 2013·Actas urologicas españolas·F Q YangX Li
Jul 20, 2016·Journal of Clinical Medicine·Joema Felipe LimaJohn M S Bartlett

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Datasets Mentioned

BETA
E-GEOD-16873

Methods Mentioned

BETA
laser capture microdissection
GTPase

Software Mentioned

R
ArrayExpress
GeneAnnot

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