PMID: 6989505Jan 1, 1980Paper

Cell-production rates estimated by the use of vincristine sulphate and flow cytometry. II. Correlation between the cell-production rates of ageing ascites tumours and the number of S phase tumour cells

Cell and Tissue Kinetics
I H Barfod, N M Barfod

Abstract

A new method for the evaluation of cell production rates combining flow cytometry (FCM) and the stathmokinetic method using vincristine sulphate (VS) has been used for the analysis of three aneuploid ascites tumours at different stages of growth. Using this technique it was possible to estimate the well-known decrease in cell production rates of ageing ascites tumours. The percentage of normal host cells in the aneuploid tumours studied was easily determined by FCM prior to the calculation of the tumour cell-production rates. A correlation was found between the percentage of tumour cells in the S phase and the tumour cell-production rate. This correlation is probably explained by the gradual transfer of proliferating cells in S phase to resting G1 and G2 phases with increasing tumour age.

References

Jan 1, 1975·Advances in Cancer Research·E H CooperT E Kenny
Jul 1, 1973·Cell and Tissue Kinetics·P DombernowskyN R Hartmann
Jul 1, 1973·Cell and Tissue Kinetics·P Bichel, P Dombernowsky
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Apr 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P K Lala
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Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·P K Lala, H M Patt

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Citations

Jan 1, 1993·Biology of the Cell·C Jayat, M H Ratinaud
Sep 1, 1984·Regulatory Toxicology and Pharmacology : RTP·E B Siegel
Sep 15, 1982·Analytical Biochemistry·H S Kruth
Sep 24, 2009·Journal of Clinical Laboratory Analysis·Roger S RileyJonathan M Ben-Ezra

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