PMID: 591660Sep 1, 1977

Cell proliferation in the Lichen planus infiltrate. Investigations by light- and electron-microscopic autoradiography

Journal of Cutaneous Pathology
H Ebner, W Jurecka

Abstract

In seven patients suffering from lichen planus (LP) light- and electron-microscopic 3H-thymidine (3HT) labeling studies were performed and the following results were obtained. 1. Using the light-microscope, a large number of 3HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei belong to mononuclear, 'round cells' while isolated endothelial cells, fibroblasts, histiocytes and mast cells could be found labeled. 2. The mean labeling index of 'round cells' in our patients was 4.27 +/- 1.57%. 3. The evaluation of the electron microscopic autoradiographs showed that, as far as 'round' cells were concerned, exclusively nuclei of cells showing the morphological criteria of stimulated lymphocytes were labeled. These findings support the view that in LP, as in allergic contact dermatitis, a high proliferative activity of lymphocytes takes place.

References

Dec 1, 1975·The British Journal of Dermatology·J H SauratA Puissant
Jan 1, 1976·Journal of Cutaneous Pathology·H Ebner, W Gebhart
Sep 1, 1975·The British Journal of Dermatology·R S TanJ P Hayes
Jun 1, 1975·The British Journal of Dermatology·V C Adreev, I Petkov
Oct 3, 1973·Histochemie. Histochemistry. Histochimie·B M Kopriwa
Feb 1, 1974·Oral Surgery, Oral Medicine, and Oral Pathology·G HeydenH Gisslén
Mar 1, 1972·The British Journal of Dermatology·M M Black
Aug 1, 1973·The British Journal of Dermatology·J M Lachapelle, M De la Brassinne
Sep 1, 1953·The Journal of Investigative Dermatology·H SHATINE L WORTHINGTON
Oct 1, 1958·A.M.A. Archives of Dermatology·W R BUCKLEY
Jul 1, 1959·A.M.A. Archives of Dermatology·O CANIZARES

Citations

Jan 1, 1988·Archives of Dermatological Research·R TammiJ E Fraki
Jan 1, 1986·Archives of Dermatological Research·M FimianiL Andreassi
Feb 1, 1979·Journal of Cutaneous Pathology·R K Winkelmann, R B Harris
Sep 1, 1996·Journal of Psycholinguistic Research·Y S LeeL H Wurm
Jul 18, 1977·Medical Microbiology and Immunology·B S RalovichM Woodbine

Related Concepts

Autoradiography
Cell Division Phases
Lichen Planus
Lymphoid Cells
Electron Microscopy
Skin

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