Cell proliferation measured by MIB1 and timing of surgery for breast cancer

British Journal of Cancer
L S CooperD M Barnes

Abstract

We have investigated the use of the antibody MIB1 as a proliferative and prognostic marker in breast cancer and whether changes in proliferative activity could account for differences in prognosis of premenopausal women operated on during different phases of the menstrual cycle. MIB1 expression was strongly correlated with S-phase fraction and histological grade. There was no difference in MIB1 scores between different phases of the menstrual cycle. Both MIB1 score and timing of surgery correlated significantly with duration of survival, while the two together were even stronger predictors of overall survival. Women with slowly proliferating tumours surgically removed in the luteal phase had a very good prognosis, whereas women with rapidly proliferating tumours excised at other times of the cycle had a worse prognosis.

Citations

Aug 22, 2000·Journal of Surgical Oncology·W J Hrushesky
May 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Manuel Neves-E-Castro
Jul 9, 2013·Pathology Oncology Research : POR·Golan BubisLea Rath-Wolfson
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·D M Barnes
Feb 24, 2001·The American Journal of Dermatopathology·L X LiJ J Kril
Jun 9, 2006·Diagnostic Pathology·A BuhmeidaY Collan
Aug 16, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ken HerrmannAndreas K Buck

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