Cell regulation by phosphotyrosine-targeted ubiquitin ligases

Molecular and Cellular Biology
Jonathan A CooperShawn S C Li

Abstract

Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degradation by the lysosome or proteasome, these E3 ligases are able to potently inhibit tyrosine kinase signaling. Their loss or mutational inactivation can contribute to cancer, autoimmunity, or endocrine disorders, such as diabetes. However, these ligases also have biological functions that are independent of their ubiquitination activity. Here we review relevant literature and then focus on more-recent developments in understanding the structures, substrates, and pathways through which the phosphotyrosine-specific ubiquitin ligases regulate diverse aspects of cell biology.

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W Y LangdonH C Morse
Jun 26, 1997·Nature·R StarrD J Hilton
Nov 5, 1997·Biochemical and Biophysical Research Communications·K MatuokaT Takenawa
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonN A Nicola
Jun 5, 1998·The Journal of Biological Chemistry·H WatermanY Yarden
Jul 22, 1998·Molecular and Cellular Biology·M A MurphyD D Bowtell
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·R StarrW S Alexander
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaramuraH Gu
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·T NakaT Kishimoto
Oct 6, 1999·Current Biology : CB·Y Hakak, G S Martin
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·K F HarrisP M Howley
Apr 5, 2000·The Journal of Biological Chemistry·P De SepulvedaR Rottapel
Jul 13, 2000·Nature·D MetcalfW S Alexander
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·C B Thien, W Y Langdon
Jul 13, 2001·The Journal of Biological Chemistry·M YokouchiR Baron
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A W RobertsW S Alexander
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangN A Nicola
Feb 12, 2002·Nature Cell Biology·Yasuyuki FujitaWalter Birchmeier
Apr 19, 2002·Nature·Ning ZhengNikola P Pavletich
Jun 8, 2002·Molecular and Cellular Biology·Danielle L KrebsWarren S Alexander
Jun 22, 2002·Trends in Biochemical Sciences·Benjamin T KileDouglas J Hilton
Sep 5, 2002·The Journal of Biological Chemistry·Christopher J GreenhalghDouglas J Hilton
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jing BaoYosef Yarden

❮ Previous
Next ❯

Citations

Jan 13, 2016·Trends in Immunology·Christoph A ThaissEran Elinav
Apr 1, 2016·Cell Division·Fumihiko OkumuraTakumi Kamura
Aug 24, 2017·Molecular Reproduction and Development·Andy Golden
Aug 11, 2017·Journal of Cell Science·Brandy D HyndmanLois M Mulligan
Nov 1, 2016·Journal of Virology·Bart M MaślikowskiPierre-André Bédard
Feb 24, 2018·Scientific Reports·Raquel CastosaAngélica Figueroa
Sep 9, 2017·Scientific Reports·Carissa Pilling, Jonathan A Cooper
Jun 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viktória FisiTamás Nagy
Jun 12, 2020·International Journal of Molecular Sciences·Haidong Gu, Behdokht Jan Fada
Nov 2, 2018·Nature Communications·Tomonori KanekoShawn S-C Li
Nov 2, 2018·Cell Death & Disease·I-Che ChungLih-Chyang Chen
Dec 31, 2020·APL Bioengineering·Sahak Z Makaryan, Stacey D Finley
Oct 30, 2020·Cancers·Andrea Rodríguez-AlonsoAngélica Figueroa
May 29, 2021·European Journal of Pharmacology·Juan-Juan MaYan-Ni Liu
Mar 16, 2017·Science Signaling·Bálint MészárosZsuzsanna Dosztányi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Science's STKE : Signal Transduction Knowledge Environment
A SanjayR Baron
World Journal of Clinical Oncology
Barbara C SnoekGodefridus J Peters
Plant Signaling & Behavior
Hongxia Liu, Sophia L Stone
© 2021 Meta ULC. All rights reserved