Cell regulation of collagen fibril macrostructure during corneal morphogenesis.

Acta Biomaterialia
Elena KoudounaJames V Jester

Abstract

While tissue form and function is highly dependent upon tissue-specific collagen composition and organization, little is known of the mechanisms controlling the bundling of collagen fibrils into fibers and larger structural designs that lead to the formation of bones, tendons and other tissues. Using the cornea as a model system, our previous 3 dimensional mapping of collagen fiber organization has demonstrated that macrostructural organization of collagen fibers involving interweaving, branching and anastomosing plays a critical role in controlling mechanical stiffness, corneal shape and refractive power. In this work, the cellular and mechanical mechanisms regulating critical events in the assembly of collagen macrostructure are analysed in the developing chicken cornea. We elucidated the temporal events leading to adult corneal structure and determined the effects of intraocular pressure (IOP) on the organization of the collagen macrostructure. Our findings indicate that the complex adult collagen organization begins to appear on embryonic day 10 (E10) after deposition of the primary stroma and full invasion of keratocytes. Importantly, organizational changes in keratocytes appearing at E9 preceded and predicted later change...Continue Reading

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Citations

Jun 4, 2020·Investigative Ophthalmology & Visual Science·Eleanor M FeneckKeith M Meek
Aug 17, 2020·Scientific Reports·Elena KoudounaPeter Lwigale
Aug 25, 2019·Experimental Eye Research·Robert D YoungAndrew J Quantock
Sep 25, 2020·Experimental Eye Research·Aurélien TiduVincent M Borderie
Jan 27, 2022·Journal of Biophotonics·Yang-Fang Chen, Chen-Yuan Dong

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