Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field

Biomaterials
Jaeha ShinMisun Cha

Abstract

Magnetic nanoparticles are widely used in bioapplications such as imaging and targeting tool. Their magnetic nature allows for the more efficient bioapplications by an external field gradient. However their combined effects have not yet been extensively characterized. Herein, we first demonstrate the biological effects of the communications between internalized bacterial magnetic nanoparticles (BMPs) and an external static magnetic field (SMF) on a standard human cell line. Combination of the BMPs and SMF act as the key factor leading to the alteration of cell structure and the enhanced cell growth. Also, their interaction reduced the apoptotic efficiency of human tumor cells induced by anticancer drugs. Microarray analysis suggests that these phenomena were caused by the alterations of GPCRs-mediated signal transduction originated in the interaction of internalized BMPs and the external SMF. Our findings may offer new approach for targeted cell therapy with the advantage of controlling cell viability by magnetic stimulation.

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Citations

Mar 19, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jaeha ShinMisun Cha
Jul 25, 2014·Chemical Communications : Chem Comm·Jing YuYanglong Hou
Jun 26, 2012·Chemical Communications : Chem Comm·Jungin ChoiMisun Cha
Jan 21, 2015·Marine Drugs·Ana Carolina V AraujoUlysses Lins
May 1, 2021·International Journal of Molecular Sciences·Sara De VincentiisVittoria Raffa
Jul 16, 2021·Nanoscale Advances·Frank MickoleitJoachim H Clement

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