Cell shape: effects on gene expression and signaling

Biophysics Reviews
Payam Haftbaradaran Esfahani, Ralph Knöll

Abstract

The perception of biophysical forces (mechanosensation) and their conversion into chemical signals (mechanotransduction) are fundamental biological processes. They are connected to hypertrophic and atrophic cellular responses, and defects in these processes have been linked to various diseases, especially in the cardiovascular system. Although cardiomyocytes generate, and are exposed to, considerable hemodynamic forces that affect their shapes, until recently, we did not know whether cell shape affects gene expression. However, new single-cell trapping strategies, followed by single-cell RNA sequencing, to profile the transcriptomes of individual cardiomyocytes of defined geometrical morphotypes have been developed that are characteristic for either normal or pathological (afterload or preload) conditions. This paper reviews the recent literature with regard to cell shape and the transcriptome and provides an overview of this newly emerging field, which has far-reaching implications for both biology, disease, and possibly therapy.

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Citations

Oct 30, 2020·Nucleic Acids Research·Nikolaos-Kosmas ChlisFabian J Theis
Dec 9, 2020·Biophysics Reviews·Damien Hall
Apr 21, 2021·Journal of Biomechanical Engineering·Alex KhangMichael S Sacks
Sep 13, 2021·Biophysical Journal·Kerbaï Saïd ErouméAurélie Carlier

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Methods Mentioned

BETA
PCA
nuclear translocation

Software Mentioned

COMSOL Multiphysics
COMSOL
VCell

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