Cell Signaling in Neuronal Stem Cells

Cells
Elkin Navarro QuirozGustavo Aroca Martinez

Abstract

The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

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Citations

Apr 2, 2019·BioMed Research International·Anna M Kamelska-SadowskaIreneusz M Kowalski
Nov 14, 2019·International Journal of Molecular Sciences·Chiara ArgentatiSabata Martino
Nov 8, 2018·International Journal of Molecular Sciences·Chiara ArgentatiSabata Martino
Aug 11, 2020·Reviews in the Neurosciences·Hamidreza ArzaghiHamidreza Pazoki-Toroudi
Mar 17, 2020·Biosensors & Bioelectronics·Jong Min LeeBong Geun Chung
Apr 9, 2021·Expert Opinion on Biological Therapy·William Brett McIntyreMichael G Fehlings
Jun 18, 2021·World Journal of Stem Cells·Xi-Min HuKun Xiong
Nov 30, 2021·Journal of Functional Biomaterials·Sahitya Chetan PandanaboinaAnindya Ghosh

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Methods Mentioned

BETA
ubiquitination
gene knockout

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