Cell signaling underlying the pathophysiology of pneumonia

American Journal of Physiology. Lung Cellular and Molecular Physiology
A PrinceJahar Bhattacharya

Abstract

The symposium addressed the burgeoning interest in fundamental mechanisms underlying the onset of pneumonia. Bacteria exploit the lung's innate immune mechanism, resulting in pathophysiological cell signaling. As a consequence inflammation develops, leading to pneumonia. New mechanisms have been identified by which bacteria or bacterial products in the airway induce cross-compartmental signaling that leads to inflammatory consequences. The speakers addressed activation of the transcription factor, NF-kappaB occurring as a consequence of bacterial interactions with specific receptors, such as the Toll-like receptors and the TNF receptor 1 (Prince), or as a consequence of cytokine induction (Mizgerd). Also considered were mechanisms of bacterial virulence in the clinical setting (Wiener-Kronish) and the role of alveolar-capillary signaling mechanisms in the initiation of lung inflammation.

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Citations

Sep 23, 2009·Critical Care Medicine·Kevin W McConnellCraig M Coopersmith
Aug 18, 2010·Infection and Immunity·Chuan-Sheng LinHsin-Chih Lai
Nov 19, 2008·Infection and Immunity·Ann CraigSamithamby Jeyaseelan
Nov 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bryan P HurleyBeth A McCormick
Jun 12, 2013·European Journal of Internal Medicine·Gurdeep Singh MannuPhyo Kyaw Myint
Sep 5, 2013·The EMBO Journal·Saswati PandaJeak Ling Ding
Dec 29, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph P Mizgerd, Shawn J Skerrett
Dec 20, 2008·Journal of Receptor and Signal Transduction Research·Stefanie EichstaedtJan-Peter Hildebrandt
Dec 23, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sabine BelowJan-Peter Hildebrandt
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudra BhowmickJohn M Leong
Dec 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saswati Panda, Jeak L Ding
Oct 10, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·David L TamangBryan P Hurley
Sep 28, 2021·New Microbes and New Infections·Z M HollidayA Krvavac

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