Cell signaling: what is the signal and what information does it carry?

FEBS Letters
Roger Brent

Abstract

This paper reviews key findings from quantitative study of the yeast pheromone response system. Most come from single cell experiments that quantify molecular events the system uses to operate. After induction, signal propagation is relatively slow; peak activity takes minutes to reach the nucleus. At each measurement point along the transmission chain, signal rises, overshoots, peaks, and declines toward steady state. At at least one measurement point, this decline depends on negative feedback. The system senses and relays percent receptor occupancy, and one effect of the feedback is to maximize precision of this transmitted information. Over time, the system constantly adjusts quantitative behaviors to convey extracellular ligand concentration faithfully. These behaviors and mechanisms that control them are likely to be general for metazoan signaling systems.

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Citations

Jun 23, 2011·Journal of Proteome Research·Bo ZhangRobert Powers
Apr 13, 2012·PloS One·Long YanHongli Wang
Jun 4, 2011·Journal of Signal Transduction·Agnès MiermontPascal Hersen
Nov 17, 2009·FEBS Letters·Marc Vidal
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Apr 13, 2011·Current Biology : CB·Lee Bardwell
Oct 23, 2015·PLoS Computational Biology·Hirenkumar K MakadiaRajanikanth Vadigepalli
Apr 6, 2018·Molecular Systems Biology·C Gustavo PesceRoger Brent
Dec 31, 2016·Molecular Systems Biology·Alan BushAlejandro Colman-Lerner
Jul 19, 2019·The Journal of Cell Biology·Frank van DrogenMatthias Peter
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Aug 25, 2018·Essays in Biochemistry·John G AlbeckAlexander E Davies
Oct 20, 2020·Molecular Systems Biology·Taryn E GilliesJohn G Albeck
Nov 11, 2019·Emerging Topics in Life Sciences·Colleen Mulvihill, Andrew Ellington

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