Cell size regulation in bacteria

BioRxiv : the Preprint Server for Biology
Ariel Amir


Various bacteria such as the canonical gram negative Escherichia coli or the well-studied gram positive Bacillus subtilis divide symmetrically after they approximately double their volume. Their size at division is not constant, but is typically distributed over a narrow range. Here, we propose an analytically tractable model for cell size control, and calculate the cell size and inter-division time distributions, and the correlations between these variables. We suggest ways of extracting the model parameters from experimental data, and show that existing data for E. coli supports partial size control, and a particular explanation: a cell attempts to add a constant volume from the time of initiation of DNA replication to the next initiation event. This hypothesis accounts for the experimentally observed correlations between mother and daughter cells as well as the exponential dependence of size on growth rate. PACS numbers: 87.17.Ee, 87.17.Aa, 87.10.Mn, 87.81Tt

Related Concepts

Cell Division
Escherichia coli
Gram-Negative Bacteria
Theoretical Model
Gram-Positive Rods (bacteria)
DNA Replication
Regulation of Biological Process
PACS1 protein, human

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.