Cell-Specific "Competition for Calories" Drives Asymmetric Nutrient-Energy Partitioning, Obesity, and Metabolic Diseases in Human and Non-human Animals.

Frontiers in Physiology
Edward ArcherJames O Hill

Abstract

The mammalian body is a complex physiologic "ecosystem" in which cells compete for calories (i.e., nutrient-energy). Axiomatically, cell-types with competitive advantages acquire a greater number of consumed calories, and when possible, increase in size and/or number. Thus, it is logical and parsimonious to posit that obesity is the competitive advantages of fat-cells (adipocytes) driving a disproportionate acquisition and storage of nutrient-energy. Accordingly, we introduce two conceptual frameworks. Asymmetric Nutrient-Energy Partitioning describes the context-dependent, cell-specific competition for calories that determines the partitioning of nutrient-energy to oxidation, anabolism, and/or storage; and Effective Caloric Intake which describes the number of calories available to constrain energy-intake via the inhibition of the sensorimotor appetitive cells in the liver and brain that govern ingestive behaviors. Inherent in these frameworks is the independence and dissociation of the energetic demands of metabolism and the neuro-muscular pathways that initiate ingestive behaviors and energy intake. As we demonstrate, if the sensorimotor cells suffer relative caloric deprivation via asymmetric competition from other cell-typ...Continue Reading

References

May 1, 1979·The American Journal of Physiology·M N Goodman, N B Ruderman
Jan 1, 1978·The American Journal of Clinical Nutrition·A HägerU Smith
Jun 1, 1978·Genetical Research·D S FalconerR C Roberts
Nov 1, 1978·Diabetologia·A KervranA Jost
Jan 1, 1978·Endocrine Research Communications·Y Yukimura, G A Bray
Jan 1, 1977·Metabolism: Clinical and Experimental·L Herberg, D L Coleman
Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Jun 4, 1992·The New England Journal of Medicine·K C SchoendorfD Rowley
Jan 1, 1991·Sports Medicine·J L Ivy
Nov 1, 1990·The Journal of Clinical Investigation·F ZurloE Ravussin
Apr 1, 1989·The Journal of Clinical Investigation·M D JensenJ M Miles
Dec 1, 1988·The American Journal of Physiology·A D BaronS V Edelman
Jan 1, 1988·Acta geneticae medicae et gemellologiae·M A Ramos-ArroyoJ C Christian
Mar 1, 1988·Journal of Applied Physiology·W R FronteraW J Evans
May 1, 1985·The American Journal of Physiology·D E JamesE W Kraegen
Jul 1, 1985·The Journal of Clinical Investigation·O Björkman, L S Eriksson
Nov 1, 1985·The American Journal of Clinical Nutrition·S C WoodsB Jeanrenaud
Oct 1, 1985·Acta diabetologica latina·M CigoliniO Bosello
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T J Case, M E Gilpin
Apr 1, 1973·The Journal of Clinical Investigation·L B SalansR E Weismann
Dec 1, 1973·Genetical Research·D S Falconer
Apr 1, 1972·British Medical Journal·C G BrookO H Wolf
Jun 1, 1983·Metabolism: Clinical and Experimental·W P Newman, R G Brodows
Feb 1, 1981·The American Journal of Physiology·L J BradyN B Ruderman
Nov 1, 1981·The American Journal of Physiology·J L Ivy, J O Holloszy
Nov 1, 1995·The American Journal of Clinical Nutrition·M I Friedman
May 12, 1995·Early Human Development·A A BrooksH I Abdalla
Apr 1, 1993·Journal of Animal Science·G A MaríaL D Van Vleck
Aug 1, 1995·Seminars in Perinatology·C J Hogue, M A Hargraves
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·W Langhans
Jun 15, 1996·The Journal of Clinical Investigation·M RodenG I Shulman
Oct 1, 1996·Archives of Pediatrics & Adolescent Medicine·W D BarfieldS L Gortmaker
Jan 1, 1997·Journal of Internal Medicine·H SugermanL Wolfe
Mar 1, 1997·The Proceedings of the Nutrition Society·M I Friedman
Jun 20, 1998·Science·J O Hill, J C Peters
Oct 15, 1998·The American Journal of Clinical Nutrition·K R Westerterp

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Citations

Apr 21, 2020·Critical Reviews in Food Science and Nutrition·Urska DobersekEdward Archer
Aug 18, 2020·Critical Reviews in Food Science and Nutrition·Edward Archer, Bahram Arjmandi
Apr 16, 2020·International Journal of Molecular Sciences·Marica FranzagoLiborio Stuppia
Nov 7, 2019·Nutrients·Jesus Lopez-MinguezMarta Garaulet
Mar 25, 2021·Mathematical Biosciences and Engineering : MBE·Mantana Chudtong, Andrea De Gaetano

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