Feb 12, 2014

Cell specific eQTL analysis without sorting cells

BioRxiv : the Preprint Server for Biology
Harm-Jan WestraLude Franke

Abstract

Expression quantitative trait locus (eQTL) mapping on tissue, organ or whole organism data can detect associations that are generic across cell types. We describe a new method to focus upon specific cell types without first needing to sort cells. We applied the method to whole blood data from 5,683 samples and demonstrate that SNPs associated with Crohn's disease preferentially affect gene expression within neutrophils.

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Mentioned in this Paper

Quantitative Trait Loci
Whole Blood
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Organ
Gene Expression
Absolute Neutrophil Count
Sorting - Cell Movement
Analysis of Substances
Whole Blood Specimen
Cell Type

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