Cell specific eQTL analysis without sorting cells

BioRxiv : the Preprint Server for Biology
Harm-Jan WestraLude Franke

Abstract

Expression quantitative trait locus (eQTL) mapping on tissue, organ or whole organism data can detect associations that are generic across cell types. We describe a new method to focus upon specific cell types without first needing to sort cells. We applied the method to whole blood data from 5,683 samples and demonstrate that SNPs associated with Crohn's disease preferentially affect gene expression within neutrophils.

Related Concepts

Analysis of Substances
Crohn Disease
Gene Expression
Neutrophil
Organ
Whole Blood
Quantitative Trait Loci
Single Nucleotide Polymorphism
Protein Expression

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