Cell-specific expression of betaC-activin in the rat reproductive tract, adrenal and liver

Molecular and Cellular Endocrinology
E J GoldJ S Fleming

Abstract

betaC-activin expression was assessed in rat tissues, using reverse transcription and real-time polymerase chain reaction, Western blotting and immunohistochemistry with a specific monoclonal antibody. betaC-activin mRNA was predominantly expressed in liver, but significant amounts were found in rat whole pituitary extracts (n = 5), and in three of five extracts of ovary, testis, and adrenal gland. Specific betaC-activin immunoreactivity was demonstrated in the cytoplasm of hepatocytes, neurosecretory cell terminals in posterior pituitary, ovarian primordial follicles, theca interna, large luteal cells and rete ovarii, spermatogonia, pachytene spermatocytes and Leydig cells of the testis, uterine endometrium, oviduct epithelium and zona glomerulosa of the adrenal. The observation of stage-specific expression in gonadal cells suggests this activin subunit has specific roles, different from those of other activin/inhibin subunits. Small amounts of mRNA in the presence of significant betaC-activin protein highlights the importance of examining betaC-activin expression at both the mRNA and protein level.

References

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Citations

Jun 1, 2005·Cytokine & Growth Factor Reviews·Christopher M ButlerGail P Risbridger
Jan 26, 2012·Brain : a Journal of Neurology·Xing-Jun LiuXu Zhang
Apr 22, 2006·The Journal of Reproduction and Development·Yuuki UshiroYoshihisa Hasegawa
May 12, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tobias WeissenbacherIoannis Mylonas
Mar 20, 2008·World Journal of Gastroenterology : WJG·Alev DeliMichael Grusch
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Badia BarakatKate L Loveland
Sep 3, 2014·Molecular Human Reproduction·Francesco Elia MarinoElspeth Gold
Feb 18, 2016·Human Reproduction Update·R Wijayarathna, D M de Kretser
Jun 15, 2011·Molecular and Cellular Endocrinology·Phil G KnightClaire Glister
Jun 15, 2017·American Journal of Obstetrics and Gynecology·Carmen GanRanjit Manchanda
Oct 31, 2009·World Journal of Hepatology·Emanuel KreidlMichael Grusch
Jun 23, 2016·Cold Spring Harbor Perspectives in Biology·Maria Namwanje, Chester W Brown
Dec 6, 2017·Reproduction, Fertility, and Development·Karen L ReaderElspeth J Gold
Sep 26, 2006·Mutation Research·Chantal Rodgarkia-DaraMichael Grusch
Jan 31, 2012·Reproductive Biomedicine Online·R G CraythornJ E Girling

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