Cell-specific induction of mouse Cyp1a1 mRNA during development.

Proceedings of the National Academy of Sciences of the United States of America
A DeyD W Nebert

Abstract

The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively. The prototypic inducer 3-methylcholanthrene was given to the pregnant mouse, and the intrauterine response was examined with the use of in situ hybridization. During the early postimplantation stage, inducible Cyp1a1 mRNA is detected in specific cell types in the extraembryonic tissues only. This selective expression along with the lack of detectable constitutive Cyp1a1 and constitutive or inducible Cyp1a2 gene transcripts between 5.3 and 14.5 days of gestation suggest that (i) these two genes appear to play no endogenous role during differentiation and (ii) the metabolic activity of the inducible Cyp1a1 enzyme may be important to the embryo and fetus from the standpoint of protection against toxic foodstuff and other environmental chemicals.

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D R ThakkerA H Conney
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A PedersenS M Galloway
Jul 16, 1985·Biochemical and Biophysical Research Communications·C E HildebrandD W Nebert
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R Filler, K J Lew
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S M GallowayR A Pedersen

❮ Previous
Next ❯

Citations

Dec 31, 1997·Microscopy Research and Technique·K J Rich, A R Boobis
Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·C HansenH Autrup
Nov 5, 2008·Archives of Pharmacal Research·S Y Lee, Y Y Sheen
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·H C LiangD W Nebert
Oct 1, 1993·Journal of Toxicology and Environmental Health·F M Farin, C J Omiecinski
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·M J BeckC Harris
Jan 19, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brooke N NakamuraUlrike Luderer
Apr 1, 1994·The Journal of Clinical Investigation·N S ShachterJ L Breslow
Jan 1, 1993·Drug Metabolism Reviews·A P Beresford
Jul 15, 1991·Biochemical and Biophysical Research Communications·H Y YangM R Juchau
Jul 9, 2004·Toxicology and Applied Pharmacology·Mark Steven Miller
Aug 6, 2004·Toxicology Letters·Bowhan JinDoug-Young Ryu
Oct 30, 1998·Biochemical and Biophysical Research Communications·A Dey, D W Nebert
Feb 28, 2003·Chemico-biological Interactions·Charlene A McQueenMartin A Philbert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.