Cell-specific susceptibility to prion strains is a property of the intact cell.

Prion
Maria Eugenia Herva, Charles Weissman

Abstract

Prions consist of PrP (Sc), a misfolded version of the cellular protein PrP (C). They occur in a variety of strains that share the amino acid sequence of PrP but differ in phenotypic properties, such as cell tropism and pathogenicity; strain-ness is attributed to the conformation of PrP (Sc). To gain insight as to how susceptibility of cells to a given prion strain comes about, we compared amplification of RML prions by PMCA, using cell lysates from related, RML-resistant and RML-susceptible cell lines as substrate. We found that both lysates supported amplification of RML PrP (Sc) equally well, despite a 280-fold difference in the susceptibility of the cells from which they were derived. Thus, susceptibility is an attribute of the intact cell.

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Citations

Mar 13, 2014·Prion·Ilaria VanniRomolo Nonno
Jan 21, 2015·Viruses·Jacques van der MerweDebbie McKenzie
Feb 2, 2019·The Journal of Biological Chemistry·Matthew E C BourkasJoel C Watts
Apr 3, 2020·Cellular and Molecular Neurobiology·Marco ZattoniGiuseppe Legname

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