PMID: 7812180Jul 1, 1994

Cell suicide in the developing nervous system: a functional neural network model

Brain Research. Cognitive Brain Research
G D BrownI J Mitchell


A computational model of programmed cell death (PCD) in the nervous system is described. A neurobiologically realisable method for identifying and removing the least useful cells from a network is developed, and it is shown by simulation that an artificial neural network can solve difficult problems efficiently if it is given more neurons initially than it needs subsequently. The least useful neurons die off gradually after learning is complete, and the learned solution can then be maintained with a smaller number of units than were needed for initial learning. The research suggests a functional role for PCD, and how self-limiting PCD could be achieved in real neural systems.


Aug 1, 1992·Trends in Neurosciences·J Altman
Apr 3, 1992·Cell·G I EvanD C Hancock
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Jun 1, 1989·Neuron·Y A Barde
May 1, 1988·Trends in Genetics : TIG·A M Davies
Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I B Black
Mar 1, 1993·Journal of Neurochemistry·S P MahD E Bredesen
Feb 1, 1993·Current Opinion in Neurobiology·R S FreemanE M Johnson
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L T ZhongD E Bredesen
Jan 1, 1991·IEEE Transactions on Neural Networks·P Saratchandran


Aug 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierD Subtil
Feb 15, 2001·Brain Research·I E Kudryashov, I V Kudryashova
Dec 18, 2001·Brain Research. Developmental Brain Research·I E KudryashovN V Gulyaeva
Jun 14, 2000·Progress in Neurobiology·I J MitchellM R Griffiths
Mar 29, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Philip T. Quinlan
Feb 1, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Oliver PogarellKlaus Tatsch
Aug 16, 2014·Sports Biomechanics·Gerda StrutzenbergerHermann Schwameder

Related Concepts

Nervous System Structure
Problem Solving (Mental Process)
Neural Network Simulation
Apoptosis, Intrinsic Pathway

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis