Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement

Analytical Chemistry
Yuji OshikawaAkio Ojida

Abstract

Mast cells secrete histamine upon degranulation triggered by various stimuli. Herein, we report the new detection method of mast cell degranulation using the fluorescent probe capable of detection of the released histamine. The probe was designed as the Co(II) complex of a cyanine dye, which shows a turn-on fluorescence signal based on a histamine-induced coordination displacement mechanism. Fluorescence imaging using the cell surface-anchored fluorescent probe enabled the real-time detection of mast cell degranulation induced by various secretagogues.

References

May 20, 1982·Nature·T C TheoharidesP W Askenase
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori
Feb 17, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·S OguriC Suzuki
Sep 11, 2002·Annual Review of Physiology·Christian PrinzManfred Gratzl
Oct 3, 2003·Cellular and Molecular Life Sciences : CMLS·C Rodríguez-CasoM A Medina
May 30, 2006·Nature Chemical Biology·Mi Hee LimStephen J Lippard
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Niti Puri, Paul A Roche
Oct 5, 2010·Bioorganic & Medicinal Chemistry Letters·Daisuke SetoToshihiko Imato
Dec 28, 2010·Biochimica Et Biophysica Acta·Theoharis C TheoharidesDimitrios Kalogeromitros
Oct 18, 2011·Journal of the American Chemical Society·Kiyoshi SasakuraTetsuo Nagano
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Feb 28, 2013·British Journal of Pharmacology·D F Finn, J J Walsh
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
May 8, 2014·Angewandte Chemie·Daisuke AsanumaKenzo Hirose
Jun 7, 2014·Nature Reviews. Immunology·Sara Wernersson, Gunnar Pejler
Nov 13, 2014·Methods in Molecular Biology·Madeleine RådingerAlasdair M Gilfillan
Jan 30, 2015·Nature Communications·Régis JouliaEric Espinosa
Feb 27, 2015·Chemical Reviews·Lei YouEric V Anslyn
May 13, 2015·Chemical Reviews·Jiasheng WuJong Seung Kim

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Citations

Aug 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Navneet KaurNarinder Singh
Apr 27, 2021·Journal of Food Science and Technology·Bhagavathi Sundaram SivamaruthiChaiyavat Chaiyasut
May 25, 2021·Chemical Society Reviews·Hao-Ran JiaFu-Gen Wu
Jul 21, 2020·The Journal of Organic Chemistry·Natalia WolfJuergen Seibel

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