Cell surface and enzyme markers of cord blood lymphocytes

British Journal of Haematology
R FoaA V Hoffbrand

Abstract

Human cord blood (CB) lymphocytes were studied with several markers for T- and B-cells and the results compared with those of adult peripheral blood (PB) samples. The proportion of E-rosettes was significantly lower in CB (mean 24.7+/-13.5 SD) than in PB (67.5+/-7.3 SD). Treatment with neuramidase produced a marked increase in the proportion of E-rosettes in CB (mean 47 +/-13.9 SD), still below the PB values. The proportion of CB lymphocytes showing block positivity with alpha-naphthyl-acetate-esterase correlated closely with the percentage of E-rosettes in neuraminidase treated cells. The percentage of H-rosettes (human RBC) was significantly higher in CB (7.2+/-6.0) than in PB (3.2+/-1.6 SD). Re-rosetting experiments showed that in CB about 30% of the E-positive cells formed H-rosettes, in contrast to 5% in PB. These findings indicate that in CB the real number of T-lymphocytes is higher than shown by conventional E-rosette formation. The proportion of B-lymphocytes, tested by surface immunoglobulins and by rosette formation with mouse RBC (M-rosettes), was similar in CB and in adult PB. A slight increase in cells with IgM on the surface was found in CB. The overall proportion of lymphocytes with negative B and T markers in C...Continue Reading

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Citations

Nov 1, 1984·Journal of Clinical Immunology·R GerliS Davis
Sep 1, 1983·Journal of Reproductive Immunology·H ZolaP C Beverley
Oct 1, 1988·Immunology and Cell Biology·K F BradstockC Luxford
Oct 1, 1982·American Journal of Reproductive Immunology : AJRI·A VelardiM F Martelli
Dec 1, 1982·American Journal of Reproductive Immunology : AJRI·J GrozdeaA Fournie
Apr 1, 1984·Scandinavian Journal of Immunology·N Khansari, H H Fudenberg
Nov 1, 1982·Cellular Immunology·F AmbrogiB Grassi

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