Cell surface antigen expression on thymocytes: development and phenotypic differentiation of intrathymic subsets

Immunological Reviews
B J Mathieson, B J Fowlkes

Abstract

Our current working model incorporates features from both the previously accepted models of intrathymic differentiation and attempts to fit some of the more recent data regarding functional differentiation, as well as the fact that our understanding of the non-lymphoid components is only marginal at best. 1. There is indeed a high level of cell death in the cortex (in the Ly1,2,3+/L3T4+ subpopulation). However, a small proportion of cells, perhaps the blasts with the same phenotype, escape the selective environment of the cortex and migrate into the medulla. Much of the cellular division in the thymus is either inappropriate or non-productive (discussed above). This is further supported by the recent indication that several cDNA clones derived from a thymocyte library have defective reading frames resulting in incomplete genetic coding for the beta chain of the T cell receptor molecule (Hedrick et al. 1984). 2. The "cortical" versus "medullary" phenotypes fail to distinguish immature versus mature (functional) subsets. The dLy1 cells, which are among the most immature thymocytes, as discussed above, are at least partially cortisone resistant and enriched in the PNA/NAg cells (Fowlkes et al., manuscript in preparation). Furtherm...Continue Reading

References

May 1, 1976·The Journal of Experimental Medicine·J L Kadish, R S Basch
Jan 1, 1978·Immunological Reviews·O Stutman
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Apr 1, 1978·The Journal of Experimental Medicine·B J MathiesonR Asofsky
Jun 1, 1978·The Journal of Experimental Medicine·R S BaschG Goldstein
Nov 2, 1978·Nature·R ScollayI Weissman
Dec 1, 1979·European Journal of Immunology·P KisielowM Wysocka
Jan 1, 1975·Cellular Immunology·C G FathmanI L Weissman
Jan 1, 1972·Progress in Allergy·M Schlesinger
Feb 1, 1972·Transplantation·C CheersA J Davies
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old
Jun 18, 1971·Science·E Leckband, E A Boyse
Feb 1, 1973·The Journal of Experimental Medicine·I L Weissman
Aug 1, 1972·European Journal of Immunology·K ShortmanK T Brunner
Jul 1, 1967·Physiological Reviews·J F Miller, D Osoba
Oct 1, 1969·Experimental Cell Research·H Blomgren, B Andersson
Dec 1, 1970·The Journal of Experimental Medicine·J J Owen, M C Raff
Jan 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·M Brumby, D Metcalf
Aug 1, 1967·The Journal of Experimental Medicine·I L Weissman
Mar 1, 1980·The Journal of Experimental Medicine·F W ShenS P Cort

❮ Previous
Next ❯

Citations

Nov 1, 1985·Developmental Biology·E Rothenberg, J P Lugo
Mar 1, 1994·Mechanisms of Ageing and Development·M Fridkis-HareliA Globerson
Aug 1, 1988·Journal of Reproductive Immunology·H C MoscovitzM J Gibson
Feb 1, 1987·Human Immunology·O Acuto, L M Larocca
Oct 1, 1987·Human Immunology·K H Singer, B F Haynes
Jul 1, 1988·Human Immunology·S ParkE J Yunis
Jul 1, 1988·Annales De L'Institut Pasteur. Immunology·J R OrtaldoR H Wiltrout
Jan 1, 1988·Annales De L'Institut Pasteur. Immunology·E L Larsson-Sciard, A Coutinho
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J P LugoE V Rothenberg
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G StinglJ E Coligan
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R CeredigP Newman
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G StinglE M Shevach
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S M DenningB F Haynes
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Penit, S Ezine
Sep 1, 1985·The Journal of Experimental Medicine·B J FowlkesT M Chused
Jan 1, 1987·The Journal of Experimental Medicine·D J PatersonA F Williams
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Sep 1, 1989·The Journal of Experimental Medicine·O Kanagawa, R Maki
Oct 1, 1993·The Journal of Experimental Medicine·Y MatsuzakiH Nakauchi
Dec 1, 1993·The Journal of Experimental Medicine·M J SánchezJ H Phillips
Jan 1, 1987·Immunologic Research·J J van Dongen, W M Comans-Bitter
Mar 1, 1991·The International Journal of Neuroscience·R FujiwaraM M Yokoyama
Jan 1, 1993·Critical Reviews in Microbiology·F M Collins
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Simon R JunankarLisa M Coussens
Nov 15, 2006·Immunological Reviews·Aharon G Freud, Michael A Caligiuri
Dec 1, 1991·Journal of Autoimmunity·J L DavignonR A Eisenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.