Aug 1, 1985

Cell surface carbohydrates and cell recognition in Dictyostelium

Cell Differentiation
S Bozzaro

Abstract

Carbohydrate ligands and complementary receptors have been detected on the surface of Dictyostelium cells, using lectins, monoclonal antibodies, and immobilized sugar probes. They have been implicated in cell recognition processes, such as phagocytosis and intercellular adhesion, and could act as membrane signals for differentiation. Specific glycoproteins have been proposed to mediate intercellular adhesion in Dictyostelium discoideum and Polysphondylium pallidum and to account for the species-specificity of adhesion displayed by these species. Recent studies with the inhibitor of N-glycosylation, tunicamycin, and with glycosylation defective mutants suggest that some carbohydrate groups in these glycoproteins play a role in cell adhesion.

Mentioned in this Paper

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Carbohydrate nutrients
Protosteliomycetes
Discoidin-I
Cell Motility
Isolectins
Structure-Activity Relationship
Glycoproteins
Antigenic Specificity

About this Paper

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.