PMID: 6395714Dec 1, 1984

Cell-surface carbohydrates in proliferative epidermal lesions. Distribution of A, B, and H blood group antigens in benign and malignant lesions

The American Journal of Dermatopathology
G Schaumburg-LeverA Ucci

Abstract

The distribution of A, B, and H blood group antigens was studied by means of peroxidase-antiperoxidase technique in normal skin and in lesions of carcinomas in situ (solar keratoses, Bowen's disease), squamous cell carcinoma, keratoacanthomas, and verrucae. In normal skin, the epidermis of persons of blood group O showed H antigens throughout the epidermis; of blood group A, H and A antigens; and of blood group B, H and B antigens. In lesions of solar keratoses, there were no antigens of blood groups in the irregular downward proliferations. In five of 11 cases of Bowen's disease, there were no antigens of blood groups in the epidermis. In eight out of 10 cases of squamous cell carcinoma, no antigens of blood groups were found in the islands of the neoplastic process, but in two cases they were present in a patchy distribution. In the benign lesions examined, the antigens of A, B, and H blood groups were always present, although in verrucae the staining was confined to the upper layers of the epidermis only.

Citations

Jan 1, 1984·Archives of Dermatological Research·G Schaumburg-LeverW F Lever
Aug 1, 1988·Pathology, Research and Practice·X Matias-Guiu, M Guix
Jun 15, 2010·Clinics in Dermatology·Christine J Ko
Jun 1, 1985·Journal of the American Academy of Dermatology·S Amornsiripanitch

Related Concepts

Blood Group H Type 1 Antigen
Bowen's Disease
Squamous Cell Carcinoma
Differential Diagnosis
Epidermis
Peroxidase-Antiperoxidase Complex Technique
Keratoacanthoma
Keratosis Blennorrhagica
Dermatologic Disorders
Malignant Neoplasm of Skin

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