PMID: 2114524Jun 1, 1990Paper

Cell surface galactosyltransferase acts as a general modulator of rat acinar cell proliferation

Molecular and Cellular Biochemistry
M Humphreys-BeherC A Schneyer

Abstract

Several physiological parameters were examined for inducing acinar cell proliferation and corresponding increased expression of beta 1-4 galactosyltransferase. In this study, dietary changes causing acinar cell proliferation included the following: the introduction of animals to a liquid diet (causing gland atrophy) followed by reintroduction of solid chow, gustatory stimulation provided by the introduction of 0.5% citric acid to animal drinking water, and removal of the submandibular gland with subsequent reliance on the parotid gland for salivary protein. Alterations in growth factor levels were produced by injecting animals with a chronic (3 day) regimen of either nerve growth factor or epidermal growth factor. Parotid gland proliferation could be blocked in all cases except EGF by the injection of propranolol, a beta-adrenoceptor antagonist, or the galactosyltransferase specific modifier protein, alpha-lactalbumin. EGF-induced proliferation could, however, be prevented by treating the animals with monoclonal antibody to EGF receptor or galactosyltransferase modifier protein alpha-lactalbumin. These results for normal acinar cell proliferation suggest a direct role for cell surface beta 1-4 galactosyltransferase in signallin...Continue Reading

Citations

Nov 9, 2002·Autonomic Neuroscience : Basic & Clinical·A V Edwards, D A Titchen
Jan 1, 1991·Archives of Oral Biology·N MaedaM G Humphreys-Beher
Jul 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P H Weigel
Jan 27, 2016·International Journal of Toxicology·Robert W KappRichard Kraska
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K R PurushothamC A Schneyer
Sep 16, 1992·Biochemical and Biophysical Research Communications·Y NakagawaM G Humphreys-Beher

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